Endocrine Abstracts

Introduction: Bone marrow is an abundant source of adult stem cells that can differentiate into various cell types. Administration of mesenchymal stem cells (MSCs) in irradiated diabetic rat model has transiently shown to decrease blood glucose level. This study examines the effect of high dose and multiple injections of MSCs on glycaemic profile, their localisation and regeneration of islet in diabetic Wistar rat.Methods: The study was carried out in ma...

Background: In individuals with primary hyperparathyroidism (PHPT), the utility of preoperative bisphosphonate administration in prevention of post-curative-parathyroidectomy hungry bone syndrome (HBS) and effects on long-term bone accrual are uncertain.Objectives: To estimate the effect of preoperative administration of single infusion of zoledronic acid (ZA) on occurrence of HBS and gain in bone mineral density (BMD) at one year in individuals with PHP...

Introduction: Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy originating from parafollicular C-cells. It accounts for 5% of all thyroid carcinomas.Methods: A retrospective registry-based analysis of demography, clinical manifestation, genetics, management, and outcome of pathologically proven MTC cases presented in a tertiary care hospital in India was done.Results: Among 71 evaluated cases, the mean age of presenta...